Bible Verses About Discouragement and Depression

October 19, 2026

Scriptures about discouragement, despondency, sorrow, and a downcast spirit. The Bible does not use “depression” as a modern clinical diagnosis; this collection is not a substitute for professional help.

22 Scriptures · Father’s Blessing Bible

Psalm 42:5

Why are you cast down, my soul, and why are you troubled? Hope in God, for I will yet praise Him, my Savior and my God.

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Psalm 34:18

The Lord is near to the brokenhearted and saves those who are humble in spirit.

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Psalm 147:3

He heals the brokenhearted and binds up their wounds;

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Psalm 40:1–3

1 For the director of music. A psalm of David. I waited patiently for the Lord; He turned to me and heard my cry. 2 He lifted me out of the pit of destruction, out of the mud and mire; He set my feet on a rock and gave me a firm place to stand. 3 He put a new song in my mouth, a hymn of praise to our God. Many will see and fear the Lord and put their trust in Him.

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Psalm 30:5

For His anger lasts only a moment, but His favor lasts a lifetime; weeping may stay for the night, but rejoicing comes in the morning.

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Isaiah 43:2

When you pass through the waters, I will be with you; and when you pass through the rivers, they will not sweep over you. When you walk through the fire, you will not be burned; the flames will not set you ablaze.

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2 Corinthians 4:8–9

8 We are hard-pressed on every side, but not crushed; perplexed, but not in despair; 9 persecuted, but not abandoned; struck down, but not destroyed.

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Psalm 42:11

Why are you cast down, my soul, and why are you troubled? Hope in God, for I will yet praise Him, my Savior and my God.

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Psalm 43:5

Why are you downcast, O my soul, and why are you disturbed within me? Put your hope in God, for I will yet praise Him, my Savior and my God.

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Psalm 23:4

Even though I walk through the valley of the shadow of death, I will fear no evil, for You are with me; Your rod and Your staff, they comfort me.

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Lamentations 3:21–23

21 Yet I call this to mind, and therefore I have hope: 22 Because of the Lord’s loving devotion we are not consumed, for His mercies never fail. 23 They are new every morning; great is Your faithfulness!

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Isaiah 61:1–3

1 The Spirit of the Lord is upon Me, because He has anointed Me to preach the Gospel to the poor; He has sent Me to heal the brokenhearted, to proclaim deliverance to the captives and recovery of sight to the blind, to set the oppressed free, 2 to proclaim the acceptable year of the Lord and the day of vengeance of our God, to comfort all who mourn, 3 to announce to those who mourn in Zion that they will be given beauty instead of ashes, the oil of joy instead of mourning, a garment of praise instead of a spirit of despair; and they will be called oaks of righteousness, the planting of the Lord, for the glory of His name.

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Matthew 11:28

Come to Me, all who labor and are heavy laden, and I will give you rest;

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Psalm 143:7–8

7 Answer me quickly, Lord; my spirit fails. Do not hide Your face from me, lest I become like those who go down to the grave. 8 Let me hear Your lovingkindness in the morning, for I trust in You. Show me the way I should go, for I lift up my soul to You, [Lord.]

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John 16:33

I have told you these things so that in Me you may have peace. In the world you will have tribulation. But take heart; I have overcome the world.

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Psalm 55:22

Cast your burden on the Lord, and He will sustain you. He will never allow the righteous to be shaken.

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1 Kings 19:4–8

4 But he himself went a day’s journey into the wilderness and came and sat down under a broom tree. And he asked for himself that he might die and said, “It is enough, Lord; take my life, for I am no better than my fathers.” 5 Then he lay down and slept under the broom tree. Suddenly, an angel touched him and said to him, “Arise, eat.” 6 And Elijah looked, and there by his head was a baked cake and a jar of water. So he ate and drank, and lay down again. 7 And the angel of the Lord came back a second time, touched him, and said, “Arise, eat, because the journey is too great for you.” 8 So he arose, ate and drank; and strengthened by that food, he went in the strength of that food forty days and forty nights to Horeb, the mountain of God.

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Psalm 34:17

The righteous cry out, and the Lord hears, and delivers them out of all their troubles.

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2 Corinthians 1:8–10

8 For we do not want you to be unaware, brothers, of our trouble which came to us in Asia: we were burdened beyond measure, above strength, so that we despaired even of life. 9 Indeed, we had the sentence of death in ourselves, so that we should not trust in ourselves but in God who raises the dead, 10 who delivered us from so great a death, and does deliver us; in whom we trust that He will still deliver us, from such a near death,

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Psalm 94:19

When my anxious thoughts multiply within me, Your consolations delight my soul.

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Psalm 119:28

My soul languishes from sorrow; strengthen me according to Your word.

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Psalm 13:1–2

1 For the director of music. A psalm of David. How long, Lord, will You forget me forever? How long will You hide Your face from me? 2 How long must I wrestle with my thoughts and have sorrow in my heart day [and night]? How long will my enemy triumph over me?

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